PYRIMIDINE NUCLEOSIDES, METHODS OF SYNTHESIS, PHARMACEUTICAL COMPOSITION Russian patent published in 1998 - IPC

Abstract RU 2116306 C1

FIELD: organic chemistry, heterocyclic compounds. SUBSTANCE: invention proposes new derivatives of pyrimidine of the general formula (I) and (II) and their salts where R1 means hydroxyl or amino-group that can be substituted with acyl-group; R2 means hydrogen atom or alkyl-group containing 1-4 carbon atoms; R3 means hydrogen atom or hydroxyl group; each of R4 and R5 means hydrogen atom, or they together can form the group R6R7-Si-O-Si-R6′R7′ where R6,R7,R6′ and R7′ can be similar or to be distinct each of other and each means C1-C4-alkyl. The claimed compounds show high antitumor activity and can be used as intermediate compounds for synthesis of the benefit antitumor agents. EFFECT: improved method of synthesis, enhanced antitumor activity. 50 cl, 4 dwg, 4 tbl, 29 ex

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RU 2 116 306 C1

Authors

Tokhru Ueda

Akira Matsuda

Takuma Sasaki

Dates

1998-07-27Published

1991-06-13Filed