FIELD: bioengineering.
SUBSTANCE: invention refers to the field of bioengineering, notably to production of exendin-4 and to a pharmaceutical composition for diabetes treatment. The derivative of exendin-4 is obtained by substituting the N-ended residual of exendin-4 histidine with the fragment chosen from the group consisting of N-dimethylhistidyl, beta-hydroxy-imidazopropionyl, 4-imidazoacetyl and beta-carboxyimidazopropionyl.
EFFECT: increased stability in blood and improved activity if compared with exendin-4.
7 cl, 3 dwg, 3 tbl, 4 ex
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