IMMUNODEPRESSANT AND ANTICANCER DRUG CONTAINING HETEROCYCLIC COMPOUND AS ACTIVE INGREDIENT Russian patent published in 2012 - IPC A61P37/06 C07D413/14 A61K31/5377 A61P35/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: present invention refers to an immunodepressant based on a heterocyclic compound of formula

or to its pharmaceutically acceptable salt where X represents a nitrogen atom or CH, both or one of R₁ or R₂ represents a hydrogen atom, hydroxyl, a halogen atom, an amino group, C₁-C₆ alkoxy or C₁-C₆ alkyl: R₃ represents a hydrogen atom, difluoromethyl, an amino group, methyl or hydroxymethyl; R₄ or R₅ represents a hydrogen atom or C₁-C₆ alkyl; R₆ represents morpholino (optionally substituted by one or two C₁-C₆ alkyl groups), pyrrolidinyl (optionally substituted by hydroxy C₁-C₆ alkyl), piperidine (which is optionally substituted by an oxygen atom, hydroxyl, formyl or C₁-C₆ alkyl), piperazinyl (optionally substituted by one or two oxygen atoms, where a nitrogen atom in position 4 is optionally substituted by a substitute selected from a groups consisting of formyl, C₁-C₆ hydroxyalkyl, C₁-C₆ alkoxycarbonyl, C₁-C₆ oxoalkyl, furoyl, benzoyl, methoxybenzoyl, benzylcarbonyl, dimethylcarbamoyl, diethylcarbamoyl, morpholinocarbonyl and methoxyacetyl) or 1,4-diazepano (optionally substituted by one oxygen atom where a nitrogen atom in position 4 is optionally substituted by a substitute selected from a group consisting of formyl, C₁-C₆ oxoalkyl). Also, the invention refers to a heterocyclic compound of general formula

and to an anticancer drug based on the compound of formula (II).

EFFECT: there are produced new immunodepressant based on the compound of formula (I) and compound of formula (II) which can be used as anticancer drugs.

12 cl, 8 tbl, 60 ex