FIELD: organic chemistry.
SUBSTANCE: invention relates to the field of organic chemistry, namely to a condensed heterocyclic compound of Formula II-1 or to its pharmacologically acceptable salt, in which R14 is selected from: 4-hydroxy piperidinyl, amino, cyclopropylamino, N,N-dimethylamino, N,N-diethylamino, N-methylpiperazinyl a, N-ethylpiperazinyl, N-isopropylpiperazinyl, C1-C6alkyl, -O-C6-C10aril group; R34 is selected from C1-C6alkyl; R44 is selected from C1-C6alkyl. The invention also relates to a compound of Formula II-2, a compound of Formula II-3, a compound of Formula II-4, a compound of Formula III, specific compounds and their pharmaceutically acceptable salts, as well as their use.
EFFECT: new condensed heterocyclic compounds have been obtained that inhibit the activity of Mst1/2 kinase, useful for the treatment or prevention of diseases associated with neurological disorders and vascular diseases associated with local ischemia.
14 cl, 3 dwg, 3 tbl
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