FIELD: chemistry.
SUBSTANCE: invention relates to a compound of formula
or tautomer thereof
or enantiomer or physiologically acceptable salt, where R1 is o-bromo, R2 is n-fluoro, R3 is C1-C4 alkyl, R6 is thiazolyl-2-yl, X is methylene and Z is morpholinyl. The invention also relates to methods of producing (versions) compounds of formula (I) and (Ia). The compound of formula (I) or (Ia) is used to prepare a pharmaceutical composition for treating or preventing HBV infections and HBV-induced diseases such as hepatitis B.
EFFECT: bromophenyl substituted thiazolyl dihydropyrimidines for HBV infection control.
20 cl, 7 tbl, 14 ex
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Authors
Dates
2012-02-27—Published
2008-06-18—Filed