BROMOPHENYL SUBSTITUTED THIAZOLYL DIHYDROPYRIMIDINES Russian patent published in 2012 - IPC C07D417/14 A61K31/5377 A61P31/12 

Abstract RU 2443703 C2

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula

or tautomer thereof

or enantiomer or physiologically acceptable salt, where R1 is o-bromo, R2 is n-fluoro, R3 is C1-C4 alkyl, R6 is thiazolyl-2-yl, X is methylene and Z is morpholinyl. The invention also relates to methods of producing (versions) compounds of formula (I) and (Ia). The compound of formula (I) or (Ia) is used to prepare a pharmaceutical composition for treating or preventing HBV infections and HBV-induced diseases such as hepatitis B.

EFFECT: bromophenyl substituted thiazolyl dihydropyrimidines for HBV infection control.

20 cl, 7 tbl, 14 ex

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RU 2 443 703 C2

Authors

Sigfrid Goldmann

Li Tszin

Lju Isun

Dates

2012-02-27Published

2008-06-18Filed