CHROMENONE COMPOUNDS AS PI3-KINASE INHIBITORS FOR TREATING CANCER Russian patent published in 2016 - IPC C07D413/14 C07D417/14 A61K31/5377 A61K31/541 A61P35/00 

FIELD: pharmaceutics.

SUBSTANCE: invention relates to chrome neon compounds with formula I possessing properties of PI3-kinase enzymes inhibitor or its pharmaceutically acceptable salts, pharmaceutical compositions based on them. In general formula I R¹ represents C_1-4alkyl, possibly substituted hydroxy; R² represents C_1-4alkyl; or R¹ and R² form together 4-6-member nitrogen-containing heterocyclic ring system which optionally contains 1 additional heteroatom selected from oxygen and sulphur, where sulphur ring atom is optionally oxidated with formation of S-oxide(-s), where said ring is possibly substituted with hydroxy; R³ and R⁵ are independently selected from H, halogen, C_1-3alkoxy and cyano; R⁴ represents H or fluorine; n equals to 0 or 1.

EFFECT: prevention and treatment of tumours sensitive to inhibition of PI3-kinase enzymes.

15 cl, 4 dwg, 3 ex, 1 tbl