FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to novel compounds of the formula (I) 
where R0 means phenyl; R1 means phenyl, heteroaryl, lower alkyl that can be free or substituted; R2 means free or substituted phenyl, lower alkyl; R3 means hydrogen atom, acyl-group, sulfonyl-group; X and Y mean independently nitrogen or carbon atom; Z is methylene group. These compounds show inhibitory activity with respect to proteases of chymotrypsin type and can be used as inhibitors of indicated enzymes, especially as inhibitors of chymase and as an active component in pharmaceutical composition. Invention relates to a novel method of synthesis of derivatives of acetamide of the formula (I) by oxidation of compound of the formula (II) 
after removal of protective group of indicated compound if it presents. EFFECT: new compounds indicated above, improved method of their synthesis, valuable biochemical properties. 24 cl, 17 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| DERIVATIVES OF PHENANTHRIDINIUM SHOWING ANTITUMOR ACTIVITY, METHOD OF INHIBITION OF CANCER CELLS GROWTH | 1997 |
|
RU2183626C2 |
| METHOD OF PREPARING OPTICALLY ACTIVE ESTERS OF ERYTHRO-3-AMINO-2- HYDROXYBUTYRIC ACIDS AND CORRESPONDING ACIDS | 1997 |
|
RU2169138C2 |
| 3-PHENYLCINNOLIN ANALOGUE AND BASED ON IT ANTI-TUMOR AGENT | 2003 |
|
RU2324683C2 |
| METHOD FOR IDENTIFICATION OF ANTI-TUMOR TARGET ENZYMES | 2002 |
|
RU2319482C2 |
| 22-THIAVITAMIN D DERIVATIVES, METHOD OF PREPARATION THEREOF, METHOD FOR PREPARATION OF COMPOUNDS, AND COMPOUNDS | 1995 |
|
RU2142941C1 |
| [1,2,4]TRIAZOLO[1,5-a]PYRIMIDINE-2-YLUREA DERIVATIVE AND ITS APPLICATION | 2004 |
|
RU2348636C2 |
| QUINOLINE AND QUINAZOLINE DERIVATIVES | 2000 |
|
RU2256654C2 |
| SYNTHESIS OF CARBAMOIL-PYRIDONE INHIBITORS OF HIV INTEGRASE AND INTERMEDIATE COMPOUNDS | 2013 |
|
RU2638923C2 |
| DERIVATIVES OF 2-THIOURACIL WITH ANTIADENOVIRAL ACTIVITY | 2017 |
|
RU2670204C1 |
| HYDRAZINE DERIVATIVE, INSECTICIDAL COMPOSITION, METHOD OF CONTROLLING PESTS, PROCESS FOR PREPARING HYDRAZINE DERIVATIVE | 1992 |
|
RU2041220C1 |
