MEDIUM AND METHOD FOR DETECTION OF MULTIPLY MODIFIED BLOOD SERUM LIPOPROTEINS Russian patent published in 2012 - IPC G01N33/49 G01N33/92 

FIELD: medicine.

SUBSTANCE: invention provides a medium for detection of the presence of multiply modified blood serum lipoproteins (mmLP) which contains 10% PVP-12600 in 0.01M Tris-HCl-buffer, pH 7.4, containing 0.15M NaCl. Also, what is described is a method for detection of the presence of multiply modified blood serum lipoproteins (mmLP) by turbodimetric opacity test wherein serum is processed in a medium characterised in cl.1 in the volumetric serum to medium ratio (1:8), incubated for 10 min. at room temperature; the test and control are measured for light absorbance at wave length 450 nm, their difference is calculated. And if the difference exceeds 2.7 standard units, the presence of multiply modified blood serum lipoproteins is stated.

EFFECT: invention provides detecting pre-clinical atherosclerosis condition, can be used as a specific marker for atherosclerotic therapy, promotes the in-depth study of atherosclerosis pathogenesis, enables its early diagnosis, as well as ensures controlling efficacy of the performed therapy.

2 cl, 10 tbl, 9 ex