METHOD FOR DETERMINING LYSIS MULTIPLE MODIFIED LOW DENSITY LIPOPROTEIN Russian patent published in 2016 - IPC G01N33/48 G01N33/52 

FIELD: biochemistry.

SUBSTANCE: invention relates to clinical chemistry and is a process for determining the lytic activity of multiply modified low-density lipoprotein (mmLNP) by treatment with 20% serum solution of polyvinylpyrrolidone having a molecular weight of 35,000 (PVP-35000) at a volume ratio of serum: PVP (1:0.84), incubated for 10 minutes at room temperature, aggregates were pelleted by centrifugation mmLNP, decanted, the sediment was dissolved in buffer mmLNP without PVP added autologous standardized washed human red blood cells, incubated for 48 hours at room temperature, the absorbance was measured in a photometer at a wavelength of 620 nm, the calibration curve is determined and the degree of lysis the lysis of more than 10% ascertain mmLNP increased lytic activity.

EFFECT: invention provides methods for determining the expansion of the arsenal of political activity mmLNP.

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