SUBSTITUTED DIHYDROQUINAZOLINES HAVING ANTIVIRAL PROPERTIES Russian patent published in 2009 - IPC C07D403/04 C07D405/14 A61K31/517 A61P31/12 

FIELD: chemistry, medicine.

SUBSTANCE: invention refers to the new substituted dihydroquinazolines of formula (I) and to their pharmaceutically acceptable salts having antiviral properties. In general formula (I) , Ar is phenyl group which can be mono-, di- or trisubstituted. The substituting group are independently selected from the group including C_1-6 alkyl-, C_1-6 alkoxy-, trifluoromethyl groups and halogen atoms or two substituting groups together with linked carbon atoms form 1,3-dioxolane; R¹ is hydrogen atom, amine group, C_1-6 alkyl group, C_1-6 alkoxy group, C_1-6 alkylthiol group, cyanic group, halogen atoms, nitro group or trifluoromethyl group; R² is hydrogen atom, C_1-6 alkyl group, C_1-6 alkoxy group, C_1-6 alkylthiol group, cyanic group, halogen atoms, nitro group or trifluoromethyl group; R³ is C_1-6 alkyl group, C_1-6 alkoxy group, C_1-6 alkylthiol group, cyanic group, halogen atoms, nitro group or trifluoromethyl group; or one of the radicals R¹, R² and R³ is hydrogen atom and two others together with linked carbon atoms form cyclopentane or cyclohexane ring, R⁴ is hydrogen atom or C_1-6 alkyl group, R⁵ is hydrogen atom or alkyl group, R⁶ is carboxyl, aminocarbonyl, alkoxycarbonyl groups, halogen atoms, cyanic or hydroxyl groups, R⁷ is hydrogen atom or halogen atoms and R⁸ is hydrogen atom or halogen atoms, its pharmaceutically acceptable salts.

EFFECT: claimed compounds can find application for treatment and prevention of diseases and as antiviral agents.

21 cl, 3 tbl, 201 ex