DERIVATIVES OF 4-AMINOBENZOPYRANE Russian patent published in 2006 - IPC C07D311/68 C07D311/70 A61K31/353 A61P9/00 

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to novel derivatives of benzopyrane of the formula (I): wherein each R¹ and R² represent independently (C₁-C₆)-alkyl group; R³ represents hydroxyl group; R⁴ represents hydrogen atom; R⁶ represents hydrogen atom; R⁷ represents hydrogen atom; X is absent or represents C=O; R⁸ represents hydrogen atom or (C₁-C₆)-alkyl group; R⁹ represents nitro-group; Y represents (C₃-C₈)-alkylene group, group -(CH₂)_m-CR¹¹R¹²-(CH₂)_n- wherein M and n are equal and each means independently 0, 1, 2, 3 or 4; m + n = 2 or above; when m = 0 then each R¹¹ and R¹² represents independently (C₁-C₆)-alkyl group or hydroxyl group; Y represents group -(CH₂)_o-O-(CH₂)_p- wherein o and p are equal and each means independently 2, 3 or 4; R⁵ represents hydrogen atom, amino-group, (C₁-C₆)-alkoxy-group, (C₃-C₈)-cycloalkyl group, (C₁-C₆)-alkylthio-group, (C₁-C₆)-alkylamino-group, di-(C₁-C₆)-alkylamino-group, (C₁-C₆)-alkoxycarbonylamino-group, and to their pharmaceutically acceptable salts, and to an anti-arrhythmic agent.

EFFECT: valuable medicinal properties of derivatives.

7 cl, 1 tbl, 9 ex