3,3-DIINDOLYLMETHANE AND EPICATECHIN-3-GALLATE GELATIN CAPSULES AND METHOD FOR MAKING THEM Russian patent published in 2012 - IPC A61K31/404 A61K31/353 A61K9/48 A61P35/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to chemical-pharmaceutical industry, and concerns a pharmaceutical composition in the form of capsules, containing as active substances 3,3¹-diindolylmethane and epicatechin-3-gallate, and a method for making this composition. A method consists in mixing 3,3¹-diindolylmethane and epicatechin-3-gallate with a liquid fatty excipient and adding a wedding agent. In mixing, the prepared mixture is heated to 35-45°C to prepare a solution. Then the prepared solution is cooled to 22-25°C to fill gelatine capsules in the following proportions, g/capsule: 3,3'-diindolylmethane - 0.01-0.1, epicatechin-3-gallate - 0.02-0.04, liquid fatty excipient - 0.05-0.1, wedding agent - 0.4-0.45. The prepared drug in the form of soft gelatine capsules containing 3,3¹-diindolylmethane and epicatechin-3-gallate in the form of a solution, enables increasing bioavailability of the active substances.

EFFECT: prepared drug is non-toxic, safe in prolonged introduction, has no local irritant action, no toxic effect on the immune and reproductive systems.

5 cl, 6 ex, 7 tbl, 4 dwg