METHOD FOR PRODUCING GELATINE CAPSULES OF 3,3-DIINDOLYLMETHANE Russian patent published in 2012 - IPC A61K31/404 A61K47/44 A61K47/46 A61K9/48 A61J3/07 A61P35/00 A61P29/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to chemical-pharmaceutical industry, particularly a technology of a new dosage form of 3,3¹-diindolylmethane. A method consists in mixing 3,3¹-diindolylmethane and a liquid fatty excipient and adding a wedding agent. In mixing, the prepared mixture is heated to 35-45°C to prepare a solution. Then the prepared solution is cooled to 21-23°C to fill gelatine capsules in the following proportions, g/capsule: 3,3¹-diindolylmethane - 0.01-0.1, the liquid fatty excipient - 0.05-0.1, the wedding agent 0.4-0.45. The prepared drug in the form of soft gelatine capsules containing 3,3¹-diindolylmethane in the form of the solution enables higher bioavailability of the active substance.

EFFECT: prepared drug is non-toxic, safe in prolonged introduction, has no local irritant action, no toxic effect on the immune and reproductive systems.

4 cl, 4 dwg, 7 tbl, 6 ex