FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to novel derivatives of 1,3-dihydro-5-isobenzofurancarbonyl of formula 1, 
or their pharmaceutically acceptable salts, where R1 represents phenyl, phenyl substituted with C1-C6-alkyloxy, phenyl, substituted with C1-C6-alkyl, phenyl, substituted with C1-C6-dialkylamine, phenyl, substituted with halogen or thienyl; R2 is selected from group consisting of C1-C6-dialkylamino, pyrazolyl and imidazolyl, excluding C1-C6-dialkylamino, if R1 represents phenyl, phenyl substituted with halogen; n represents integer number from 1 to 3, and method of their obtaining.
EFFECT: invention also relates to pharmaceutical compositions, which include formula 1 compound, and method of treatment and prevention of premature ejaculation.
18 cl, 8 tbl, 68 ex
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