FIELD: medicine, pharmaceutics.
SUBSTANCE: inventions relate to field of biotechnology. iRNK-agents contain sense strand, where said sense strand contains in internal area 15-30 successive nucleotides, which differ from nucleotides of SEQ ID NO:427 sequence not more than by one nucleotide, and antisense strand, where said antisense strand contains in internal area 15-30 successive nucleotides, which differ from nucleotide of SEQ ID NO:428 sequence by not more than one nucleotide.
EFFECT: iRNA agents can contain modifications, which increase their stability in biological sample, cholesterol molecule, non-natural nucleotide base, iRNA-agents are applied for inhibition of expression of PB2 gene of influenza A virus.
73 cl, 9 dwg, 6 tbl, 3 ex
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