STRAIN OF INFLUENZA VIRUS GKV 2389 FOR PRODUCTION OF LIVING INTRANASAL AND INACTIVATED INFLUENZA VACCINE Russian patent published in 2008 - IPC C12N7/00 C12R1/93

Abstract RU 2318871 C1

FIELD: medical virology.

SUBSTANCE: vaccine strain A/17/duck/Potsdam/86/92 (H5N2) No 2389 represents reassortant obtained by apathogenic avian virus A/17/duck/Potsdam/1402-6/86 (H5N2) with cold adapted temperature sensitive strain A/Leningrad/134/17/57 (H5N2). Strain is reproduced in hen embryo at 37°C, characterized by cold adaptation and temperature sensitivity, has H5N2 gene derived from attenuation donor and encoding of surface glycoprotein and hemagglutinine, six genes encoding of non-glycosilated proteins and neuroamidinase gene.

EFFECT: safe and effective strain active against H5N1 viruses.

8 tbl, 2 ex

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RU 2 318 871 C1

Authors

Desheva Julija Andreevna

Rudenko Larisa Georgievna

Aleksandrova Galina Ibragimovna

Dates

2008-03-10—Published

2006-04-19—Filed