FIELD: pharmaceutics.
SUBSTANCE: invention concerns expression systems, including protein coding polynucleotides. Expression system comprises first polynucleotide coding at least one protein, peptide or their version, which induces T-cell response, and second polynucleotide coding at least one protein, peptide or their version, which induces B-cell response against pathogen. Invention also relates to mixtures of proteins coded by expression system and cells containing expression system or mixture of proteins and pharmaceutical compositions containing expression system or mixture of proteins. Invention also concerns nucleotide structures, including, mainly consisting of polynucleotide coding modified hemagglutinin (HA) of influenza virus.
EFFECT: expression system, polynucleotides, proteins, cells and pharmaceutical compositions are applicable in preventing or treating infections.
15 cl, 13 dwg, 1 tbl, 5 ex
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