VANILLOID RECEPTOR SUBTYPE 1 (VR1) ANTAGONISTS AND APPLICATION THEREOF Russian patent published in 2012 - IPC C07D491/20 C07D405/12 A61K31/416 A61P13/10 A61P43/00

Abstract RU 2450006 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: present invention refers to new compounds of formula

, where X¹, X², Y, R^1a, R^1b, R^2a, R^2b, A₁, A₂, A₃ and A₄ have the values specified in the description, which are vanilloid receptor subtype 1 (VR1) antagonists.

EFFECT: preparing a pharmaceutical composition on the basis of the compounds of formula 1 and developing methods of managing pain, neurotic pain, allodynia, inflammation or inflammatory disease associated pain, inflammatory hyperalgesia, bladder hyperactivity and urine incontinence.

22 cl, 21 ex

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RU 2 450 006 C2

Authors

Braun Brajan S.

Kenig Dzhon R.

Gomtsjan Artur R.

Li Chikh-Khung

Dates

2012-05-10—Published

2007-04-12—Filed