DERIVATIVES OF 2-AMINOPYRIDINE OR 2-AMINOPYRIMIDINE AS CYCLIN-DEPENDENT KINASE INHIBITORS Russian patent published in 2021 - IPC C07D401/14 C07D405/14 C07D487/04 C07D498/04 A61K31/506 A61K31/5383 A61K45/06 A61P35/00 

FIELD: organic chemistry; pharmacology.

SUBSTANCE: group of inventions relates to the field of organic chemistry and pharmacology, namely to compounds having the inhibitory activity of cyclin-dependent kinases (CDKs) and represented by the formula (XI), where R¹ is H, F or Cl; R² is H, C₁-C₅alkyl, C₁-C₅fluoroalkyl or C₃-C₈cycloalkyl, in which each specified C₁-C₅alkyl and C₁-C₅fluoroalkyl is optionally replaced by R²⁰ and each specified C₃-C₈cycloalkyl is optionally substituted by R²¹; R⁴ is H, C₁-C₄alkyl or C₁-C₄fluoroalkyl, in which each specified C₁-C₄alkyl and C₁-C₄fluoroalkyl is optionally substituted by R²⁰; or R² can be taken together with R⁴ to form a 6-membered heterocyclic ring, optionally containing an additional heteroatom selected from NR²⁴ and O as a member of the ring, and the ring is optionally replaced by R²¹; R⁶ is H, F or Cl; R⁷ and R⁸ are H; R⁹ is OH; each R²⁰ is independently OH or NR²²R²³; each R²¹ is independently F, NR²²R²³ or C₁-C₄alkyl; each R²² and R²³ is independently H, C₁-C₂alkyl or C₁-C₂fluoroalkyl; R²⁴ is H or C₁-C₄alkyl. In addition, a pharmaceutical composition inhibiting the activity of cyclin-dependent kinases (CDKs) containing a therapeutically effective amount of the compound of formula (XI), as well as a method for treating breast cancer, including the introduction of a therapeutically effective amount of the compound presented to the object, is described.

EFFECT: presented group of inventions provides effective treatment of breast cancer.

14 cl, 6 tbl, 149 ex