NITROGEN-CONTAINING HETEROCYCLIC AROMATIC COMPOUND, METHOD FOR PRODUCTION THEREOF, PHARMACEUTICAL COMPOSITION BASED THEREON AND USE THEREOF Russian patent published in 2020 - IPC C07D401/10 C07D405/10 C07D409/14 C07D413/10 C07D471/04 C07D487/04 C07D519/00 A61K31/437 A61K31/444 A61K31/5025 A61K31/517 A61K31/5377 A61K31/506 A61P3/10 A61P13/12 A61P17/02 A61P19/02 A61P19/10 A61P27/02 A61P31/12 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to a nitrogen-containing aromatic heterocyclic compound of formula I, or a pharmaceutically acceptable salt thereof. In formula I ring Z is 5–6-member heteroaromatic ring containing 1–3 heteroatoms, wherein heteroatom is N or selected from a group consisting of N and O, or a group consisting of N and S; ring Q is a benzene ring or 5–6-member heteroaromatic ring; ring A is an unsubstituted benzene ring or unsubstituted 6-member heteroaromatic ring; ring B is a substituted or unsubstituted 5–6-member heteroaromatic ring; wherein in the ring B definition, the substituted or unsubstituted 5–6-member heteroaromatic ring is a substituted or unsubstituted imidazole ring, a substituted pyrimidine ring, a substituted pyrazine ring, substituted or unsubstituted pyrazole ring, substituted or unsubstituted triazole ring or substituted furan ring; Z¹ is N or C; Z² is S, O, N or CR^2'; Z³ is S, N or CR^3'; Z⁴ is N, NR^a3 or CR^4'; Z⁵ is N, CR^5' or a single bond; Y¹ is S, N or CR⁴; Y² is N, NR^5y1, CR⁵ or a single bond; A¹ is C, each of A³ and A⁴ is independently N or C; A² denotes N or CR^a4; values of remaining radicals are specified in the claim. Invention also relates to individual nitrogen-containing aromatic heterocyclic compounds of formula I, to methods of producing, using and to a pharmaceutical composition.

EFFECT: technical result is obtaining novel nitrogen-containing aromatic heterocyclic compounds of formula I, having the properties of ALK5 inhibitor.

14 cl, 1 tbl