FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to a new clatrate complex of α-, β-, γ- or hydroxipropyl-β-cyclodextrine or arabinogalactane with 9-phenyl-symm-octahydroselenoxantene with formula (1) possibly - in α-crystalline form. The weight ratio of 9-phenyl-symm-octahydroselenoxantene to Cyclodextrine is from 1:3 to 1:30 or the weight ratio of 9-phenyl-symm-octahydroselenoxantene to arabinogalactane is from 1:10 to 1:20. Additionally proposed are a liquid phase method of the complex production, a solid phase method of the complex production, a pharmaceutical composition and a medication.
EFFECT: invention allows to improve water solubility and bioavailability and to reduce the toxic action of symm-octahydroselenoxantene.
16 cl, 14 dwg, 3 tbl, 1 ex
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Authors
Dates
2012-05-27—Published
2011-02-21—Filed