CLATRATE COMPLEX OF CYCLODEXTRINE OR ARABINOGALACTANE WITH 9-PHENYL-SYMM-OCTAHYDROSELENOXANTENE, ITS PRODUCTION METHOD (VERSIONS), PHARMACEUTICAL COMPOSITION AND MEDICATION Russian patent published in 2012 - IPC C07D345/00 A61K47/40 A61K47/36 C08B37/00 

Abstract RU 2451680 C1

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to a new clatrate complex of α-, β-, γ- or hydroxipropyl-β-cyclodextrine or arabinogalactane with 9-phenyl-symm-octahydroselenoxantene with formula (1) possibly - in α-crystalline form. The weight ratio of 9-phenyl-symm-octahydroselenoxantene to Cyclodextrine is from 1:3 to 1:30 or the weight ratio of 9-phenyl-symm-octahydroselenoxantene to arabinogalactane is from 1:10 to 1:20. Additionally proposed are a liquid phase method of the complex production, a solid phase method of the complex production, a pharmaceutical composition and a medication.

EFFECT: invention allows to improve water solubility and bioavailability and to reduce the toxic action of symm-octahydroselenoxantene.

16 cl, 14 dwg, 3 tbl, 1 ex

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RU 2 451 680 C1

Authors

Podgorodnichenko Vladimir Konstantinovich

Tsyb Anatolij Fedorovich

Roziev Rakhimdzhan Akhmetdzhanovich

Goncharova Anna Jakovlevna

Vorob'Ev Il'Ja Vladimirovich

Erimbetov Kenes Tagaevich

Dates

2012-05-27Published

2011-02-21Filed