FIELD: medicine.
SUBSTANCE: there are described new clathrate complexes of 7-brom-5-(ortho-chlorophenyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-one and cyclodextrin, which can find application in pharmaceutical industry, and methods for producing them. The invention also refers to compositions and medicinal agents based on the new clathrate complexes of 7-brom-5-(ortho-chlorophenyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-one and cyclodextrin. To produce the complexes, α-, β- or γ-cyclodextrins, as well as hydroxypropyl-β-cyclodextrin can be used.
EFFECT: stability and high water solubility of the produced complexes and based pharmaceutical composition.
9 cl, 7 dwg, 8 ex, 1 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| PHARMACEUTICAL COMPOSITION AND MEDICINAL PRODUCT BASED ON CLATHRATE COMPLEX OF N-CARBAMOYLMETHYL-4-PHENYL-2-PYRROLIDONE, OR 4-PHENYLPYRACETAM WITH CYCLODEXTRIN, METHOD FOR PRODUCTION (VERSIONS) | 2016 |
|
RU2640081C1 |
| COMPLEX OF RAS-FARNESYLTRANSFERASE INHIBITOR, COMPOSITION OF RAS-FARNESYLT RANSFERASE INHIBITOR, PHARMACEUTICAL COMPOSITION | 1999 |
|
RU2230062C2 |
| PURIFIED DERIVATIVES OF SULFOALKYL ETHERS OF CYCLODEXTRINE OR THEIR MIXTURE, CLATRATE COMPLEX OF CYCLODEXTRINE DERIVATIVES WITH MEDICINAL, AND PHARMACEUTICAL COMPOSITION | 1993 |
|
RU2113442C1 |
| TRIAZOLO (4,3-a) 1,4 BENZO DIAZEPINES AND THRENO (3,2 | 1992 |
|
RU2094436C1 |
| METHOD OF SYNTHESIS OF 1,3-DIHYDRO-7-NITRO-5-PHENYL-2H-1,4- -BENZODIAZEPINE-2-ONE (NITRAZEPAM) (VARIANTS) | 1998 |
|
RU2150467C1 |
| CLATRATE COMPLEX OF CYCLODEXTRINE OR ARABINOGALACTANE WITH 9-PHENYL-SYMM-OCTAHYDROSELENOXANTENE, ITS PRODUCTION METHOD (VERSIONS), PHARMACEUTICAL COMPOSITION AND MEDICATION | 2011 |
|
RU2451680C1 |
| β-CYCLODEXTRINE CLATHRATE COMPLEX WITH 5-HYDROXY-4-AMINOMETHYL-1 -CYCLOHEXYL(OR CYCLOHEPTYL)-3-ALKOXYCARBONYLINDOLE DERIVATIVE, METHOD FOR PREPARING IT (VERSIONS), PHARMACEUTICAL COMPOSITION AND DRUG | 2011 |
|
RU2464042C1 |
| CLATHRATE COMPLEXES OF BETA-CYCLODEXTRIN WITH 1-{[6-BROMO-1-METHYL-5-METHOXY-2-PHENYLTHIOMETHYL-1-H-INDOL-3-YL]CARBONYL}-4-BENZYLPIPERAZINE, HAVING ANTIVIRAL ACTIVITY, SYNTHESIS AND USE THEREOF | 2010 |
|
RU2448120C1 |
| METHOD OF PRODUCING 7-BROMO-5-(2-CHLOROPHENYL)-1,3-DIHYDRO-2H-1,4-BENZODIAZEPIN-2-ONE | 2015 |
|
RU2599988C1 |
| ISOINDOLINONE INHIBITORS OF MDM2-P53 INTERACTION WITH ANTI-CANCER ACTIVITY | 2016 |
|
RU2794333C1 |
