FIELD: medicine.
SUBSTANCE: there are described new clathrate complexes of 7-brom-5-(ortho-chlorophenyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-one and cyclodextrin, which can find application in pharmaceutical industry, and methods for producing them. The invention also refers to compositions and medicinal agents based on the new clathrate complexes of 7-brom-5-(ortho-chlorophenyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-one and cyclodextrin. To produce the complexes, α-, β- or γ-cyclodextrins, as well as hydroxypropyl-β-cyclodextrin can be used.
EFFECT: stability and high water solubility of the produced complexes and based pharmaceutical composition.
9 cl, 7 dwg, 8 ex, 1 tbl
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