QUATERNARY AMMONIUM DIPHENYLMETHYL COMPOUNDS USED AS MUSCARINIC RECEPTOR ANTAGONISTS Russian patent published in 2012 - IPC C07D207/08 C07D207/09 C07D207/46 A61K31/40 A61P11/00 

FIELD: chemistry.

SUBSTANCE: invention relates to novel compounds of formula l , where a and b are independently equal to 0-5; R¹ and R² independently denote -C_1-4alkyl, CN, halogen, -OR^a, -CH₂OH, R^a independently denotes H, C_1-4alkyl; R³ denotes -C(O)NR^3aR^3b, -CN; R^3a and R^3b denote H; R⁵ denotes -C_1-6alkyl; Q denotes -C_0-5-alkylene-Q'-C_0-1alkylene-, Q' denotes -CH₂-, -CH=CH-, -C≡C-, -O-, -S-, -S(O)-, -SO₂-, -C(O)-, -OC(O)-, -C(O)O-, -NR^Q1C(O)-, -C(O)NR^Q1-, -NR^Q2-C(O)-NR^Q3-, -C=N-O-, -S-S- and -C(=N-O-R^Q4)-, R^Q1 denotes H; R^Q2 and R^Q3 denote H; R^Q4 denotes -C_1-4alkyl, benzyl; e equals 0-5; R⁶ independently denotes halogen, -C_1-4alkyl, -C_0-4alkylene-OH, CN, -C (O)O-C_1-4alkyl, -O-C_1-4alkyl, -S-C_1-4alkyl, -NH-C(O)-C_1-4alkyl, -N (C_1-4alkyl)₂ and -N⁺(O)O; where the alkyl group in R⁶ is optionally substituted with 1-5 F atoms; one -CH₂- group in Q is optionally substituted with one -OH; or a pharmaceutically acceptable salt or zwitterion form thereof.

EFFECT: compounds exhibit antagonistic activity towards muscarinic receptors, which enables their use to produce pharmaceutical compositions for treating lung diseases such as chronic obstructive pulmonary disease and asthma.

32 cl, 16 ex