AMINE COMPOUND AND PHARMACEUTICAL USE THEREOF Russian patent published in 2012 - IPC C07C217/64 C07C317/22 C07C323/19 C07C323/32 C07D211/14 C07D295/08 C07D307/79 C07D317/22 C07F9/09 C07F9/655 C07D317/62 C07D333/16 C07D333/28 C07D333/56 C07F9/6553 A61K31/137 A61K31/4453 A61K31/5375 A61K31/661 A61P37/02 A61K31/36 A61P43/00 A61P37/08 A61P41/00 

FIELD: chemistry.

SUBSTANCE: invention relates to an amine compound of formula (I), pharmaceutically acceptable addition salts, hydrates or solvates thereof, having immunodepressive effect , where R - H or P(=O)(OH)₂; X - O or S; Y denotes -CH₂CH₂- or -CH=CH-; Z denotes C_1-5-alkylene, C₂-₅-alkenylene or C₂-₅-alkynylene; R₁ denotes CF₃, R₂ denotes C_1-4-alkyl, substituted with OH or halogen; R₃ and R₄ independently denotes H < or C_1-4-alkyl; A denotes optionally substituted C₆-₁₀-aryl, heteroaryl containing 5-10 ring atoms, where 1 or 2 atoms are selected from N, O and S, C_3-7-cycloalkyl optionally condensed with optionally substituted benzene, or heterocycloalkyl containing 5-7 ring atoms, where 1 or 2 atoms are selected from N and O, where said substitutes are selected from C_1-4-alkylthio, C_1-4-alkylsulphanyl, C_1-4-alkylsulphonyl, C_2-5-alkylcarbonyl, halogen, cyano, nitro, C_3-7-cycloalkyl, C_6-10-aryl, C_7-14-aralkyloxy, C_6-10-aryloxy, optionally substituted with oxo or halogen, C_2-3-alkyleneoxy, C_3-4-alkylene or C_1-2-alkylenedioxy, optionally substituted with halogen C_1-4-alkyl or C_1-4-alkoxy.

EFFECT: novel compound which is effective in reducing the level of lymphocytes in peripheral blood, suppresses tissue breakdown and exhibiting less side effects, such as bradycardia, is disclosed.

20 cl, 237 ex, 2 tbl