FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to pharmaceutics, and concerns a method for preparing a solid dispersion containing midostaurin by mixing midostaurin and polymer, poloxamers and optionally sorbitol, processing the prepared mixture on an extruder at temperature less than a degradation temperature of midostaurin that is followed by extrusion of said mixture.
EFFECT: method allows preparing a highly soluble dosage form of midostaurin.
6 cl, 2 dwg, 2 tbl
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