FIELD: chemistry.
SUBSTANCE: invention relates to a compound of general formula (I), salts and solvates thereof as ligands for G-protein conjugated receptors, , as well as a library consisting of elements which are compounds of formula (I). In general formula (I) , y equals 1 or 2; z equals 0; X denotes -CO-(Y)k-(R1)n, or SO2-(Y)k-(R1)n; k equals 0; each R1 is independently selected from hydrogen or alkyl, haloalkyl, alkoxy, haloalkoxy, alkenyl, alkynyl, alkylamino, alkylaminoalkyl, alkylaminodialkyl, having an alkylaminotrialkyl charge or having an alkylcarboxylate charge from 1-20 carbon atoms; or each R1 is independently selected from fluorine, chlorine, bromine, iodine, hydroxy, oxyalkyl, amino, aminoalkyl, aminodialkyl, having the charge of aminotrialkyl or a carboxylate radical; n is an integer from 1 to m, where m is the maximum number of allowable substitutes; R1 contains a carbon atom next to the carbonyl group of carbonamide or the sulphonyl group of sulphanilamide, which is di-substituted or identical or different groups selected from: alkyl, haloalkyl, alkoxy, haloakoxy, alkenyl, alkynyl and aklylamino radical; and the carbon atom next to the carbonyl group of carbonamide or the sulphonyl group of sulphanilamide in R1 forms essentially tetrahedral valence-bond angles.
EFFECT: obtaining a compound, salt or solvates thereof for use as ligands for G-protein conjugated receptors.
4 cl, 4 ex
Authors
Dates
2012-06-27—Published
2005-08-10—Filed