LIGANDS FOR G-PROTEIN CONJUGATED RECEPTOR Russian patent published in 2012 - IPC C07D453/06 C07D487/08 A61K31/55 A61K31/439 A61P43/00 

Abstract RU 2454416 C2

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of general formula (I), salts and solvates thereof as ligands for G-protein conjugated receptors, , as well as a library consisting of elements which are compounds of formula (I). In general formula (I) , y equals 1 or 2; z equals 0; X denotes -CO-(Y)k-(R1)n, or SO2-(Y)k-(R1)n; k equals 0; each R1 is independently selected from hydrogen or alkyl, haloalkyl, alkoxy, haloalkoxy, alkenyl, alkynyl, alkylamino, alkylaminoalkyl, alkylaminodialkyl, having an alkylaminotrialkyl charge or having an alkylcarboxylate charge from 1-20 carbon atoms; or each R1 is independently selected from fluorine, chlorine, bromine, iodine, hydroxy, oxyalkyl, amino, aminoalkyl, aminodialkyl, having the charge of aminotrialkyl or a carboxylate radical; n is an integer from 1 to m, where m is the maximum number of allowable substitutes; R1 contains a carbon atom next to the carbonyl group of carbonamide or the sulphonyl group of sulphanilamide, which is di-substituted or identical or different groups selected from: alkyl, haloalkyl, alkoxy, haloakoxy, alkenyl, alkynyl and aklylamino radical; and the carbon atom next to the carbonyl group of carbonamide or the sulphonyl group of sulphanilamide in R1 forms essentially tetrahedral valence-bond angles.

EFFECT: obtaining a compound, salt or solvates thereof for use as ligands for G-protein conjugated receptors.

4 cl, 4 ex

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RU 2 454 416 C2

Authors

Grehjndzher Dehvid Dzhon

Foks Dehvid Dzhon

Dates

2012-06-27Published

2005-08-10Filed