1,3-DIHYDROIMIDAZOLE-2-THIONE DERIVATIVES AS DOPAMINE-BETA-HYDROXYLASE INHIBITORS Russian patent published in 2013 - IPC C07D405/04 A61K31/4178 A61P25/00 A61P29/00 

FIELD: chemistry.

SUBSTANCE: invention relates to novel 1,3-dihydroimidazole-2-thione derivatives of formula I: , in which R₁, R₂ and R₃, identical or different, denote hydrogen or halogen; R₄ denotes alkyl aryl; X denotes an oxygen atom; n equals 2 or 3; individual (R)-enantiomers thereof; or pharmaceutically acceptable salts thereof, where the term "alkyl" denotes straight or branched hydrocarbon chains which contain one to six carbon atoms; the term "aryl" denotes a phenyl or naphthyl group; the term "halogen" denotes fluorine, chlorine, bromine or iodine. The invention also relates to a method of producing said compounds, a pharmaceutical composition based on said compounds, having inhibiting action on dopamine-beta-hydroxylase, methods of treating different cardiovascular diseases such as hypertension and chronic heart failure, and use of compounds of formula 1 to produce drugs for treating said diseases.

EFFECT: improved properties of derivatives.

32 cl, 2 dwg, 1 ex