FIELD: biotechnology, molecular biology, medicine, proteins.
SUBSTANCE: invention describes nucleotide sequence encoding new polypeptide (TIE-ligand-4) that relates to the family of TIE-ligands. Fragment of this nucleotide sequence relating to fibrinogen-like domain of new polypeptide is determined. Vectors comprising nucleic acid fragment with sequence encoding TIE-ligand-4 or its fibrinogen-like domain are constructed and used for transformation of host-cells and preparing corresponding recombinant polypeptides. Application of TIE-ligand-4 as component of conjugate with cytotoxic agent and its fibrinogen-like domain for formation of "ligand-body" is proposed.
EFFECT: improved preparing method, valuable biological and medicinal properties of ligand.
14 cl, 10 dwg, 14 ex
| Title |
Year |
Author |
Number |
| ISOLATED NUCLEIC ACID MOLECULE ENCODING CHIMERIC TIE-2-LIGAND (VARIANTS), CHIMERIC OR MODIFIED TIE-2-LIGAND AND METHOD FOR ITS PREPARING, VECTOR, METHOD FOR PREPARING SYSTEM VECTOR-HOST, CONJUGATE, PHARMACEUTICAL COMPOSITION |
1997 |
- Dehvis Sehmjuel'
- Jankopoulos Dzhordzh D.
|
RU2233880C2 |
| NUCLEIC ACID MOLECULE ENCODING LIGAND TIE-2, LIGAND TIE-2 AND METHOD FOR ITS PREPARING, VECTOR, STRAIN OF CELLS COS, ANTIBODY, CONJUGATE OF LIGAND TIE-2, LIGAND BODY, PHARMACEUTICAL COMPOSITION, METHOD FOR PROPHYLAXIS OR ATTENUATION OF NEOVASCULARIZATION AND METHOD FOR IDENTIFICATION OF TIE-2 RECEPTOR ANTAGONIST |
1995 |
- Dehvis Sehmjuehl'
- Bruno Dzhoan
- Goldfarb Mitchell
- Oldrich Tomas Kh.
- Mehjsonp'Er Piter S.
- Radzievski Cheslav
- Dzhons Pamela F.
- Jankopulos Dzhordzh D.
|
RU2233330C2 |
| ISOLATED NUCLEIC ACID MOLECULE ENCODING LIGAND TIE-2, LIGAND TIE-2 AND METHOD FOR PREPARING, PLASMID (VARIANTS), ANTIBODY, CONJUGATE, LIGAND BODY, PHARMACEUTICAL COMPOSITION, METHOD FOR STIMULATING NEO-VASCULARIZATION, METHOD FOR CELL MAINTENANCE, METHOD FOR IDENTIFYING TIE-2 RECEPTOR ANTAGONIST |
1995 |
- Dehvis Sehmjuehl'
- Bruno Dzhoan
- Goldfarb Mitchell
- Oldrich Tomas Kh.
- Mehjsonp'Er Piter S.
- Radzievski Cheslav
- Dzhons Pamela F.
- Jankopulos Dzhordzh D.
|
RU2232812C2 |
| RECEPTOR BODY SPECIFICALLY BINDING LIGAND TIE-2, ISOLATED NUCLEIC ACID MOLECULE, PLASMID, PHARMACEUTICAL COMPOSITION AND METHOD FOR PREVENTION OR ATTENUATION OF NEOVASCULARIZATION IN MAMMALS |
1995 |
- Dehvis Sehmjuehl'
- Bruno Dzhoan
- Goldfarb Mitchell
- Oldrich Tomas Kh.
- Mehjsonp'Er Piter S.
- Radzievski Cheslav
- Dzhons Pamela F.
- Jankopulos Dzhordzh D.
|
RU2216593C2 |
| ISOLATED NUCLEIC ACID ENCODING FELINE LIGAND CD86, DIAGNOSTIC OLIGONUCLEOTIDE, CLONING VECTOR, VACCINE, METHODS FOR INDUCTION OR SUPPRESSION OF IMMUNITY IN CAT |
1999 |
- Kollison Ehllen V.
- Choj In-Soo
- Uinslou Barbara Dzh.
- Kochran Mark D.
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RU2263145C2 |
| VECTORS CONDITIONALLY EXPRESSING THERAPEUTIC PROTEINS, HOST CELLS COMPRISING THE VECTORS, AND USES THEREOF |
2011 |
|
RU2612788C2 |
| DNA MOLECULE ENCODING POLYPEPTIDE ABLE TO BIND WITH INTRACELLULAR DOMAIN OF FAS (FAS-IC) LIGAND RECEPTOR, POLYPEPTIDE, METHOD FOR ITS PREPARING, VECTOR, METHOD FOR MODULATION OF EFFECT OF FAS-R LIGAND ON CELLS (VARIANTS), PHARMACEUTICAL COMPOSITION (VARIANTS), METHOD FOR ISOLATION AND IDENTIFICATION OF PROTEIN |
1995 |
- Uollakh Dehvid
- Boldin Mark
- Varfolomeev Evgenij
- Mett Igor'
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RU2241747C2 |
| POLYPEPTIDE-LIGAND FLT3 (VARIANTS), POLYNUCLEOTIDE (VARIANTS), EXPRESSING VECTOR (VARIANTS), STRAIN OF CELL CHO (VARIANTS), METHOD FOR PRODUCING POLYPEPTIDE-LIGAND FLT3 (VARIANTS), PHARMACEUTICAL COMPOSITION (VARIANTS) |
1994 |
- Lajmehn Stjuart D.
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RU2220979C2 |
| NUCLEIC ACIDS, CODING RECEPTOR CTLA-4 OF CAT, VECTORS, HOST CELLS, VACCINES, OLIGONUCLEOTIDES, POLYPEPTIDES CTLA-4 OF CAT AND METHODS FOR INDUCTION AND SUPPRESSION OF IMMUNE RESPONSE IN CAT |
1999 |
- Kollison Ehllen V.
- Choj In-Soo
- Uinslou Barbara Dzh.
- Kochran Mark D.
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RU2377302C2 |
| ANTIBODIES AGAINST ANGIOPOIETIN-2 AND USE THEREOF |
2005 |
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- Chzhou Tsin
- Kejt Brjus A.
- Jan Sjao-Dun
- Emeri Stefen Charl'Z
- Blejki Dehvid S.
|
RU2394839C2 |
