CARDIOPROTECTION TECHNIQUE Russian patent published in 2012 - IPC A61M5/00 A61K38/17 A61K47/48 A61P9/10 B82B1/00 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely cardiology, and may be used for myocardium protection against ischemic and reperfusion injures. That is ensured by the target drug delivery to the ischemic-reperfused myocardium. Aminated silica nanoparticles of the diameter of 10 nm wherein a spacer is grafter are used as a drug carrier. A drug substance is immobilised on a functional group of the spacer by one of the following methods: covalent binding, coordination ion interaction, immobilisation by adsorption.

EFFECT: technique provides the selective accumulation of the drug substance within ischemia-reperfusion after the systemic introduction of the specified complex with the minimum effect of the preparation on intact organs and tissues and good biodegradability of the carrier; surface functionalisation of said nanoparticles also provides a binding ability of the drug substances of different chemical compositions in various proportions.

2 tbl