SYNTHESIS OF R-5-(2-(2-(2-ETHOXYPHENOXYETHYLAMINO)PROPYL)-2-METHOXYBENZENE SULPHONAMIDE HYDROCHLORIDE OF HIGH CHEMICAL PURITY Russian patent published in 2012 - IPC C07C303/40 C07C303/44 C07C311/37 A61K31/18

Abstract RU 2456269 C2

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing tamsulosin hydrochloride. The method involves reaction of R-5-(2-aminopropyl)-2-methoxybenzene sulphonamide molar excess of 1-(2-bromoethoxy)-2-ethoxybenzene which ranges from about 1.3 to about 3, in an organic solvent. Said organic solvent is methanol. The method further involves purification of the obtained tamsulosin hydrochloride by recrystallising tamsulosin hydrochloride from a solution in methanol or ethanol or from a mixture of ethanol and methanol. Recrystallisation is carried out from a mixture of methanol and ethanol in ratio from about 3:7 to about 7:3.

EFFECT: high optical purity of the desired tamsulosin hydrochloride.

5 cl, 7 ex

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RU 2 456 269 C2

Authors

Furlan Borut

Tsopar Anton

Dates

2012-07-20—Published

2004-12-27—Filed