TRICYCLIC COMPOUND AND ITS PHARMACEUTICAL APPLICATION Russian patent published in 2012 - IPC C07D263/52 C07D277/60 A61K31/423 A61K31/428 A61P25/00

Abstract RU 2456278 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to compounds of general formula (I) wherein R¹represents (a) C_1-6alkyl optionally containing 1-3 substitutes specified in C_1-6alkylcarbonyloxy, hydroxy and a halogen atom, (b) C_3-6cycloalkyl, (c) phenyl or (d) mono-C_1-6alkylamino; R⁵ represents a hydrogen atom; R⁶represents a hydrogen atom; X represents an oxygen atom or a sulphur atom; m is equal to 1; the ring A is an unsaturated 5-member ring optionally containing a substitute specified in (a) C_1-6alkyl optionally containing 1-3 substitutes specified in phenyl, hydroxy and a halogen atom, C_1-6alkylcarbonyl, benzyloxy and pyridyl, (b) C_3-6cycloalkyl, (c) phenyl or (d) C_1-6alkoxy, (e) mercapto, (f) C_1-6alkylthio or (g) di-C_1-3alkylamino; the ring B is an unsubstituted phenyl; the ring C is a saturated or unsaturated 5-member ring optionally containing a substitute specified in C_1-6alkyl and hydroxy. Also the invention refers to the intermediate compounds of formula (II) and to the pharmaceutical composition containing the compounds of formula (I) showing melatonin agonist activity.

EFFECT: preparing the compounds of formula (I) as melatonin agonists.

14 cl, 7 dwg, 2 tbl, 98 ex

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RU 2 456 278 C2

Authors

Utikava Osamu

Kojke Tatsuki

Khoasi Jasutaka

Takai Takafumi

Dates

2012-07-20—Published

2007-06-18—Filed