NEW SUBSTITUTED BIARYL COMPOUNDS AS INDOLAMINE-2,3-DIOXYGENASE (IDO) INHIBITORS Russian patent published in 2022 - IPC C07D305/08 C07D405/10 C07D405/14 C07D417/10 C07D471/04 A61K31/337 A61K31/4155 A61K31/427 A61K31/4427 A61P35/00 A61P35/02 

FIELD: biotechnology.

SUBSTANCE: invention relates to a compound of the formula (I) or its pharmaceutically acceptable salt, which have inhibitory activity relatively to indolamine-2,3-dioxygenase (hereinafter – IDO). In the specified formula, n is 1; p is 1; in each case, A is -CH=; M is -O-; R¹ is pyridinyl, where pyridinyl is optionally substituted with 1-3 substitutes independently selected from: (a) halogen, (b) -C_3-8-cycloalkyl optionally substituted with -OH, (e) -O-C_1-8-alkyl optionally substituted with 1-5 halogen atoms, (f) -O-C_3-8-cycloalkyl, (g) -C_1-8-alkyl optionally substituted with 1-4 substitutes independently selected from halogen, -OH, -NH₂, (i) -C(O)-R^f, where R^f is selected from -OH, -NH₂, and -NH-C_1-8-alkyl; R² is phenyl, where phenyl is optionally substituted with 1-3 substitutes independently selected from: (a) halogen, (c) -CN, (d) -O-C_1-8-alkyl optionally substituted with 1-3 halogen atoms, and (e) -C_1-8-alkyl optionally substituted with 1-3 substitutes independently selected from halogen; and R³ is selected from H and halogen. The invention also relates to a pharmaceutical composition inhibiting IDO and containing a pharmaceutically acceptable carrier and effective amount of the compound of the formula (I) or its pharmaceutically acceptable salt and to a separate compound of N-(4-fluorphenyl)-3-(4-(4-(2-hydroxypropane-2-yl)-6-(trifluoromethyl)pyridine-3-yl)phenyl)oxetane-3-carboxamide or its pharmaceutically acceptable salt.

EFFECT: obtainment of compounds for inhibition of indolamine-2,3-dioxygenase.

(I)

16 cl, 16 tbl, 152 ex