METHOD FOR DETERMINING SEVERITY IN PATIENTS WITH BRONCHOPULMONARY DISEASES Russian patent published in 2012 - IPC G01N33/48 

FIELD: medicine.

SUBSTANCE: invention involves patient's induced sputum sampling, cell substance recovery and preparation for the examination. A cell alteration value is determined by apoptosis evaluation, while the cell substance is additionally examined for a cell necrosis alteration value. The apoptosis and necrosis values are determined in two or more examinations every 1-3 days. The derived values are expressed in the form of a necrosis index (NI) and an apoptosis index (AI) to calculate a cell alteration index (CAI) by formula: CAI=NI/AI, wherein NI is the necrosis index; AI is the apoptosis index. A severe clinical course of the bronchopulmonary disease is stated by the CAI values within 0.5 to 1.0. A moderate degree of severity is shown by the CAI values falling within the range 1.0 to 1.3. And a mild degree is indicated by the CAI values in the range 1.3 to 1.7. The clinical effectiveness of the bronchopulmonary disease can be determined by comparing the initial CAI values and the CAI value during treatment, and if observing increasing the CAI values, the improvement is diagnosed.

EFFECT: using the method enables higher accuracy of determination with providing more simple and fast method.

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