METHOD FOR DIFFERENTIAL DIAGNOSTICS OF BRONCHIAL ASTHMA, CHRONIC BRONCHITIS AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE Russian patent published in 2007 - IPC A61B5/91 A61B10/00 G01N33/48 

FIELD: medicine, pulmonology.

SUBSTANCE: the present innovation deals with differential diagnostics of bronchial asthma (BA), chronic bronchitis (CB) and chronic obstructive pulmonary disease (COPD). In the course of the trial it is necessary to evaluate the following 5 significant informative values: a patient's age (a, yr); forced expiratory volume (FEV)/sec (b, %); cytosis of the induced sputum (c, 10⁶/ml); the content of neutrophils in the induced sputum (d, %) and the fact of smoking (e, 1 - smokes, 0 - doesn't smoke). Then it is necessary to calculate regression functions f_BA/COPD, f_CB/COPD according to the following formulas: f_BA/COPD=7.099176+a*(-0.10366)+b*(0.114298)+c*(-1.05833)+d*(-0.11193)+e*(-2.51857); f_CB/COPD=-9.95967+a*(-0.11273)+b*(0.228438)+c*(-0.01994)+d*(-0.03066)+e*(-0.38734). Then it is important to calculate the probability for the presence of BA, CB and COPD according to the following formulas: p_BA/COPD=f_BA/COPD/(1+_ef_BA/COPD); p_CB/COPD=_ef_CB/COPD/(1+_ef_CB/COPD), where p_BA/COPD - the probability for the presence of CB against COPD; e=2.718 - the foundation of natural logarithm. At p_BA/COPD or p_CB/COPD value ≥0.5 the probability of BA or CB is greater against COPD. At p_BA/COPD or p_CB/COPD values <0.5 the chance for COPD is greater. According to the data of these calculations it is necessary to evaluate the data obtained due to comparing them to establish the diagnosis of the disease - BA, CB or COPD, the probability of which is the highest that enables to prescribe adequate therapy in due time.

EFFECT: higher efficiency and accuracy of differential diagnostics.

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