METHOD FOR ESTIMATING EFFECTIVENESS OF ANTIMICROBIAL ACTION OF ANTIBIOTICS AND ULTRASOUND ON PATHOGENIC BACTERIA IN FORM OF BIOFILM Russian patent published in 2012 - IPC C12Q1/04 C12N13/00 

FIELD: medicine.

SUBSTANCE: clinical effectiveness is estimated on an simulation model and provides creating a model of bacterial biofilm grown on biolumenescent bacteria Vibrio fischeri. The biofilm is exposed to antibiotics and ultrasound to estimate an antimicrobial effect. The bacterial viability variation may be controlled by varying luminous intensity of the biolumenescent bacteria with using devices, e.g. lumen meters. The antimicrobial effect is estimated by a degree of luminous intensity inhibition as compared to the reference.

EFFECT: method may be applicable in pre-clinical experiments to specify the effective method of treating chronic bacterial infections complicated by bacterial biofilm formation, reduced costs and labour inputs of experiments.

25 dwg, 5 ex