FIELD: medicine, pharmaceutics.
SUBSTANCE: declared invention refers to chemical-pharmaceutical industry, and concerns orally disintegrating nicotine compositions containing lower levels of buffer agents in comparison with conventional orally disintegrating nicotine tablets. The composition of an orally disintegrating tablet contains a) a basic granular ingredient containing: at least one alkaline buffer agent; at least one dissolution modifier; and at least one excipient; the active substance nicotine; and c) at least one alkaline buffer agent.
EFFECT: compositions provide optimum oral pH and induce nicotine absorption in a smaller more convenient dosage form.
18 cl, 5 ex, 3 tbl, 3 dwg
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