HISTONE DEACETYLASE INHIBITORS Russian patent published in 2012 - IPC C07D267/20 C07D281/16 A61K31/553 A61K31/554 A61P25/14 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to compounds presented by formula (IV) or to their pharmaceutically acceptable salts: , wherein: R¹⁴⁰ specified in a group consisting of: H and halo; xa and xb mean the numbers each of which is independently specified in 0, 1 and 2; R¹⁵⁰ and R¹⁶⁰ are independently specified in a group consisting of H, halo, -CN, -CF₃, -OCF₃, -C₁-C₆alkyl, -C₁-C₆alkoxyl, -O-C₂-C₆alkyl-O-R⁵³, -OR⁵³, -C₀-C₆alkyl-S(O)_0-2-R⁵³, -C₀-C₆alkyl-C(O)NR⁵⁰R⁵¹, -C₀-C₆alkyl-heterocyclyl wherein heterocyclyl is monocyclic and contains 6 atoms, and one or two atoms are independently specified in O and N; R⁵⁰ and R⁵¹ and R⁵³ are independently specified in a group consisting of -C₁-C₆alkyl.

EFFECT: developing a pharmaceutical composition, a method for histone deacetylase inhibition and a method of treating a polyglutamate disease wherein the polyglutamate disease is Huntington's disease.

8 cl, 332 ex, 10 tbl, 91 dwg