METHOD OF PRODUCING N-NITRO-5-CHLOROMETHYLOXAZOLIDINE-1,3 Russian patent published in 2012 - IPC C07D263/04 

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing N-nitro-5-chloromethyloxazolidine-1,3, which is used as a primary product in synthesis of energetic polymer plasticisers - N-nitro-5-nitroxymethyl- and N-nitro-5-azidomethyloxazolidine-1,3, and can also be used in synthesis of biologically active substances. The method of producing N-nitro-5-chloromethyloxazolidine-1,3 is realised via successive reaction of a sulphamate with epichlorohydrin and aqueous formaldehyde solution, followed by separation of N-(5-chloromethyl-oxazolidine-1,3)-sulphamate by vacuum stripping and nitration thereof with nitric acid in the presence of acetic anhydride. The sulphamate used is a triethylammonium salt. An alcohol solution of formaldehyde is used for the cyclisation reaction. The product of cylisation of the triethylammonium salt of N-(5-chloromethyloxazolidine-1,3)-sulphamic acid is treated with an alcohol solution of potassium hydroxide; the precipitated potassium N-(5-chloromethyloxazolidine-1,3)-sulphamate is separated by filtration, dissolved in glacial acetic acid and nitrated with nitric acid in the presence of acetic anhydride at temperature 20…25°C.

EFFECT: easy implementation of the process.

1 ex