DERIVATIVES OF 1,3-DIHYDRO-2H-IMIDAZO[4,5-B]QUINOLINE-2-ONE AS AN INHIBITORS OF PHOSPHODIESTERASE, A METHOD OF ITS SYNTHESIS, INTERMEDIATE COMPOUNDS, A PHARMACEUTICAL COMPOSITION AND A METHOD OF ITS PREPARING Russian patent published in 1999 - IPC

FIELD: organic chemistry, biochemistry, pharmacy. SUBSTANCE: invention relates to derivatives of 1,3-dihydro-2H-imidazo[4,5-b]quinoline-2-one of the formula (I) where R - phenyl possibly substituted with 1-3 substituents taken from halogen, alkyl, or radical =C=O or = C= N-O-R¹ where R¹ is C_1-6-alkyl possibly substituted with COOH, COO-C_1-4-alkyl or CON-R³R⁴ where R³ is C_1-4-alkyl and R⁴ is C_3-7-alkyl or R³ and R⁴ taken together with nitrogen atom to which they are bound can form piperazine cycle, or their pharmaceutically acceptable salts, or their stereomeric forms that are able to inhibit activity of phosphodiesterase and can be used for treatment of patients with allergic and atonic sicknesses. EFFECT: improved method of synthesis, enhanced effectiveness of compounds. 12 cl, 2 tbl, 25 ex