AZOLCARBOXAMIDE COMPOUND OR ITS PHARMACEUTICALLY ACCEPTABLE SALT Russian patent published in 2012 - IPC C07D277/20 C07D263/34 C07D417/14 C07D413/12 C07D417/12 A61K31/427 A61K31/422 A61K31/421 A61K31/426 A61P13/02 

Abstract RU 2461551 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: it has been confirmed that the new azolcarboxamide compound or its pharmaceutically acceptable salt wherein a thiazole ring or an oxazole ring is bound to a benzene ring, a pyridine ring, a pyridazine ring, a thiophen ring, a pyrazole ring or a pyrrol ring through carboxamide or its ring possess high activity of receptor trkA inhibition; it has been found that they may be used as a therapeutic and/or preventive agent which is different in the fact concerning the effectiveness and safety for repeated urination, frequent micturate urge and urine incontinence associated with various urogenital diseases, including higher bladder activity, various lower bladder diseases accompanied with urogenital pain, such as interstitial cystitis, chronic prostatitis and others, and various diseases accompanied by pain; thereby the present invention has been created.

EFFECT: provided therapeutic and/or preventive agent for repeated urination, frequent micturate urge and urine incontinence associated with various urogenital diseases, including higher bladder activity, various lower bladder diseases accompanied with urogenital pain, such as interstitial cystitis, chronic prostatitis and others, and various diseases accompanied by pain on the basis of excellent inhibitory action on the receptor trkA.

24 cl, 1195 ex, 215 tbl

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Authors

Sugasava Kejzo

Kavaguti Keniti

Nomura Takakho

Matsumoto Sunitiro

Sin Takasi

Azami Khidenori

Abe Tomoaki

Suga Akira

Seo Rjusi

Tanakhasi Masajuki

Vatanabe Toru

Dates

2012-09-20Published

2008-10-23Filed