INDAZOLES, BENZOTHIAZOLES, BENZOISOTHIAZOLES, BENZOISOXAZOLES, PYRAZOLOPYRIDINES, ISOTHIAZOLOPYRIDINES, PREPARING AND USING THEM Russian patent published in 2012 - IPC C07D453/02 C07D519/00 A61K31/439 A61K31/4738 A61K31/4745 A61K31/496 A61K31/5377 A61P25/18 A61P25/24 A61P25/26 A61P25/28 A61P25/32 

FIELD: medicine, pharmaceutics.

SUBSTANCE: present invention refers to organic chemistry, namely new compounds of formula , wherein A represents residues of formulae

, , , X represents O; X¹-X⁴ represents N, CH, CR¹ or C-, X⁹-X¹² represents N, CH, CR⁴ or C-, X¹³-X¹⁶ represents N, CH, CR or C-, wherein C represents an attachment point of the group A to a residue of the structure of formula (I); R' represents H or alkyl; R represents alkoxy, or Het; R¹ represents F, CI, Br, I, OH, CN, carboxy, CONR⁶R⁷, NR²COR⁸, NR²COOR⁸, alkoxy, fluorinated alkoxy, Ar, Het or OHet; or R¹ represents one of the following formulas: wherein n is equal to 2 and m is equal to 3; R² represents H, alkyl, fluorinated alkyl, cycloalkyl, Het or Het-NH-CO-; R⁴ represents F, Cl, Br, I, OH, alkoxy, cycloalkoxy, Het or OHet; or R⁴ represents one of the following formulae: , wherein n is equal to 2 and t is equal to 3; each R⁶ and R⁷ independently represents alkyl, or cycloalkyl, or R⁶ and R⁷ together represent alkylene group containing 5-6 carbon atoms which forms a cycle with N atoms; R⁸ represent alkyl, or cycloalkylalkyl; R⁹ represents alkyl; Ar represents aryl group; Het represents heterocyclic group which is completely saturated, particularly saturated or completely unsaturated containing 5 to 10 ring atoms in which at least 1 ring atom represents N, O or S atom which is unsubstituted or substituted once or several times by the substituted specified in cl. 1; and their pharmaceutically acceptable salts or solvates or N-oxides, or solvates of their pharmaceutically acceptable salts, or solvates of N-oxides of their pharmaceutically acceptable salts wherein said compound can be presented in the form of a polymorph, wherein if said compound shows chirality, it can be presented in the form of a mixture of enanthiomers or a mixture of diastereoisomers, or can be presented in the form of single enanthiomer or single diastereoisomer; and wherein at least one of the groups R, R¹ or R⁴ represents Het or OHet, wherein the group Het is specified in each case in substituted or unsubstituted azabicyclooctyl, oxaazabicycloheptyl, diazabicycloheptyl, diazabicyclononyl, diazabicyclooctyl, pyrazolyl, dihydroimidazolyl, 1,4-diazepanyl, hezahydropyrrolopyrazinyl and octahydropyrrolopyridinyl. Also the invention refers to other compounds of formula (I), to specific compounds, to a pharmaceutical composition based on the compound of formula (I), to a method of selective activation/stimulation of α-7 nicotinic receptors, to application of the compound of formula (I) for making the drug.

EFFECT: there are produced new compounds showing effective biological properties.

53 cl, 1 tbl