SULFONAMIDE DERIVATIVES AS GLYCOKINASE ACTIVATORS APPLICABLE FOR TREATING INSULIN-DEPENDENT DIABETES Russian patent published in 2011 - IPC C07D513/04 C07D285/135 C07D213/75 C07D239/42 C07D277/46 C07D231/40 C07D277/82 C07D241/20 C07D239/84 A61K31/429 A61K31/426 A61K31/433 A61K31/4402 A61K31/505 A61K31/415 A61P3/10 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to compounds of formula

wherein Q together with carbon and nitrogen atoms whereto attached forms a 5-6-members monocyclic heteroaromatic ring; or Q together with carbon and nitrogen atoms whereto attached forms a 9-10-members bicyclic heterocycle; R₁ and R₂ independently mean hydrogen, halogen, alkyl, alkyl substituted by one or more halogen, alkoxygroup, alkoxygroup substituted by alkoxygroup, alkylthiogroup, sulphonyl, free or etherified carboxygroup, carbamoyl, sulohamoyl, morpholinyl or pyridinyl; or R₂ is absent; R₃ means (C₃-C₆)cycloalkyl; R₄ means hydrogen, halogen, lower alkyl or lowest alkyl substituted by one or more halogen; R₅ means (C₃-C₆cycloalkyl, (C₆-C₁₀) aryl, (C₃-C₁₀)heterocyclyl or (C₁-C₆)alkyl optionally substituted by (C₁-C₆)alkoxygroup, (C₃-C₇)cycloalkyl, (C₆-C₁₀)aryl or (C₃-C₁₀)heterocyclyl; R₆ means free or etherified carboxygroup; and n is an integer equal to 1-6; or to its enanthiomer, or a mixture of its enanthiomers, or its pharmaceutically acceptable salt. Besides, the invention refers to a method of glucokinase activation in mammals, to a method of treating pathological conditions associated with glucokinase activation in mammals and impaired glucose tolerance, as well as to a pharmaceutical composition based on these compounds and to application of said compositions for preparing a drug.

EFFECT: there are produced and described new compounds which are activators and can be used as therapeutic agents for treating the glucokinase mediated pathological conditions.

31 cl, 4 ex