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2 463 052

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IPC

A61K31/515(2006-01-01)

A61K31/196(2006-01-01)

A61P25/08(2006-01-01)

(21) (22)

Application

2011123713/15, 2011-06-02

(24)

Start date

2011-06-02

(22)

Actual filing date

2011-06-02

(45)

Published

2012-10-10

(72)

Inventor

Chepur Sergej ViktorovichBykov Vladimir NikolaevichIvanov Igor' MikhajlovichNikiforov Aleksandr SergeevichJudin Mikhail Anatol'EvichAnokhin Aleksandr Gennad'EvichTjunin Mikhail AleksandrovichFateev Ivan Vladimirovich

(73)

Holder

Vojskovaja Chast'

PHARMACEUTICAL COMPOSITION WITH ANTICONVULSANT ACTIVITY FOR PARENTERAL INTRODUCTION Russian patent published in 2012 - IPC A61K31/515 A61K31/196 A61P25/08

Abstract RU 2463052 C1

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to a pharmaceutical composition showing anticonvulsant activity on the basis of phenobarbital and a non-steroidal anti-inflammatory agent (fenamate) taken in molar ratio 23:5. The pharmaceutical composition is presented in the form of a dosage form for parenteral introduction and contains sodium phenobarbital 233 mg, sodium mefenamate 31.0 mg or sodium tolfenamate 33.5 mg, 1,2-propylene glycol 400 mg and ethanol 100 mg as stabilisers and hydroxypropyl-β-cyclodextrin 200 mg as an agent for prolonged release and reduced irritation, and distilled water for injections.

EFFECT: anticonvulsant composition possess high protective anticonvulsant efficacy in emergency management of convulsant poisoning, storage stability, low toxicity, high therapeutic range, prolonged action and minimally manifested local irritant action in parenteral introduction.

3 dwg, 7 tbl, 8 ex

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RU 2 463 052 C1

Authors

Chepur Sergej Viktorovich

Bykov Vladimir Nikolaevich

Ivanov Igor' Mikhajlovich

Nikiforov Aleksandr Sergeevich

Judin Mikhail Anatol'Evich

Anokhin Aleksandr Gennad'Evich

Tjunin Mikhail Aleksandrovich

Fateev Ivan Vladimirovich

Dates

2012-10-10—Published

2011-06-02—Filed