FIELD: organic chemistry. SUBSTANCE: invention describes new derivatives of cyclosporin of the general formula (I) 
where R - hydrogen atom, (C1-C3)-alkyl, (C1-C3)-alkoxy-group, (C1-C3)-alkyl-group substituted with halide, hydroxy-substituted (C1-C3)-alkyl, (C1-C2)-alkylamino or di-(C1-C2)-alkylamino-group; X - oxygen atom; x-y means -CH=CH (trans or -CH2-CH2); Q means -(D)Ala, -(D)Ser, -/O-2-hydroxyethyl- -(D)Ser or -/O-(2-acylhydroxyethyl)-(D)Ser- where each of acyl-residues is physiologically hydrolysable and acceptable. Invention describes a method of synthesis of the above indicated compounds and a pharmaceutical composition for topical administration used as an immunosuppressive or anti-inflammatory agent with pharmaceutically acceptable vehicles or carriers on the basis of compounds of the formula (I). EFFECT: improved method of synthesis, curative effect. 9 cl, 13 ex
