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2 463 596

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IPC

G01N33/49(2006-01-01)

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Application

2011116520/15, 2011-04-26

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Start date

2011-04-26

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Actual filing date

2011-04-26

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Published

2012-10-10

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Inventor

Knjazev Oleg VladimirovichLazebnik Leonid BorisovichKonopljanikov Anatolij GeorgievichParfenov Asfol'D IvanovichSagynbaeva Venera EhsambaevnaRuchkina Irina NikolaevnaJakovleva Marija Valer'EvnaAstrelina Tat'Jana Valer'EvnaLebedeva Lidija L'VovnaLychkova Alla Ehduardovna

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Holder

METHOD FOR EVALUATING CLINICAL EFFECTIVENESS OF MESENCHYMAL STROMAL CELLS FOR INFLAMMATORY INTESTINAL DISEASES Russian patent published in 2012 - IPC G01N33/49

Abstract RU 2463596 C1

FIELD: medicine.

SUBSTANCE: T- and B-lymphocyte subpopulation dynamics before and after mesenchymal stromal cell transplantation is examined. If the content of autoreactive B1 lymphocyte clone in peripheral blood is 0.027-0,013×10⁹l, the value of immunoregulatory index is 1.43-1.35, the level of CD3+CD4+CD38+ in peripheral blood is 0.12-0.22x10⁹/l, the level of CD3+CD8+CD38+ in peripheral blood is 0.057-0.073x10⁹/l, clinical effectiveness in inflammatory intestinal disease is estimated to be satistactory.

EFFECT: use of the given invention enables estimating clinical effectiveness of mesenchymal stromal cells in inflammatory intestinal disease.

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RU 2 463 596 C1

Authors

Knjazev Oleg Vladimirovich

Lazebnik Leonid Borisovich

Konopljanikov Anatolij Georgievich

Parfenov Asfol'D Ivanovich

Sagynbaeva Venera Ehsambaevna

Ruchkina Irina Nikolaevna

Jakovleva Marija Valer'Evna

Astrelina Tat'Jana Valer'Evna

Lebedeva Lidija L'Vovna

Lychkova Alla Ehduardovna

Dates

2012-10-10—Published

2011-04-26—Filed