METHODS OF PRODUCING HEXAHYDROFURO[2, 3-b] FURAN-3-OL Russian patent published in 2012 - IPC C07D307/20 C07D493/04 

Abstract RU 2464266 C2

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing a compound of formula (V) which can be used in pharmaceutical industry . The method involves reaction of a compound of formula (II) with a compound of formula (III) in the presence of a titanium salt of formula Ti(Hal)n(OR)4-n, where Hal is a halogen radical, n equals 0, 1, 2 or 3, R is an alkyl or arylalkyl, and subsequent reaction of the reaction product with an alcohol of formula (IV), where R1 and R2 denote alkyl or arylalkyl, where the aryl is phenyl or naphthyl.

EFFECT: novel efficient method of producing compounds of the given formula using novel intermediate compounds is disclosed.

16 cl, 9 ex

Similar patents RU2464266C2

Title Year Author Number
METHODS OF PRODUCING (3R, 3aS, 6aR) HEXAHYDROFURO[2,3-b]FURAN-3-OL 2005
  • Kvadflig Peter Jan Leonard Mario
  • Kestelejn Bart Rudol'F Romani
  • Vejn Robert Jan
  • Libregts Konstantinus Simon Marija
  • Koistra Jakob Khermanus Matteus Khero
  • Lommen Fransiskus Al'Fons Mari
RU2421458C2
METHOD FOR PRODUCTION OF (3R, 3aS,6aR)-HEXAHYDROFURO[2,3-b]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1- BENZYL-2-HYDROXYPROPYLURETHANE 2004
  • Gojvaerts Nikolas Marta Feliks
  • Vigerink Pit Tom Bert Pol'
  • Zintser Kharmut Burgkhard
  • Ehbert Birgit M.
RU2376308C2
RMT5 INHIBITORS 2019
  • Mashasek, Mishell
  • Vitter, Devid
  • Zhibo, Krejg
  • Khuan, Chunkhoj
  • Kavamura, Sukhei
  • Sloman, Devid, L.
  • Silipkhaivankh, Pkhieng
  • Kiros, Rajan
  • Van, Myurrej
  • Shnajder, Sebastyan
  • Jeung, Charlz, S.
  • Rojtershan, Majkl, Kh.
  • Khenderson, Timoti, Dzh.
  • Paparen, Zhan-Loran
  • Raali, Usin
  • Khyuz, Dzhonatan, M., E.
  • Sanyal, Sulagna
  • Je, Jingchun
  • Kandito, Devid, A.
  • Fajer, Patrik, S.
  • Silverman, Stiven, M.
RU2814198C2
SIMPLIFIED PROCEDURE FOR OBTAINING DARUNAVIR 2017
  • Stappers, Alfred Elisabeth
  • Lang, Yolande Lydia
  • Robinson, Shane Barry
RU2745740C2
TETRAHYDROFURO(3,2-b)PYRROL-3-ONES AS CATHEPSIN K INHIBITORS 2007
  • Kvibell Martin
  • Uotts Dzhon Pol
RU2456290C2
COMPOUNDS AND COMPOSITIONS USED FOR TREATMENT OF NTRK-RELATED DISORDERS 2016
  • Wenglowsky Steven Mark
  • Brooijmans Natasja
  • Miduturu Chandrasekhar V.
  • Bifulco Neil
RU2744974C2
SYNTHESIS OF PROTEASE INHIBITOR PRECURSOR 2006
  • Linklo Bruno
RU2421459C2
HEXAHYDROFURO[2,3-B]FURAN-3-YL-N-{3-[(1,3-BENZODIOXOL-5- YL- SULFONYL)(ISOBU TYL)AMINO]-1-BENZYL-2-HYDROXYPROPYL}CARBAMATE, PHARMACEUTICAL COMPOSITION BASED ON THEREOF, METHODS FOR INHIBITION AND METHOD FOR TREATMENT 2000
  • Vigerink Pit Tom Bert Pol'
  • Vang Guangiang
  • Ehjssensteht Majkl
  • Ehrikson Dzhon V.
RU2247123C2
ELECTRO-SPINNED AMORPHOUS PHARMACEUTICAL COMPOSITIONS 2003
  • Ignatious Frehnsis
  • San Lingkhong
RU2331411C2
METHOD FOR PREPARING (3aR, 4S, 6R, 6aS)-6-AMINO-2, 2-DIMETHYLTETRAHYDRO-3aNE-CYCLOPENTA[d][1,3]DIOXOL-4-OLE-DIBENZOYL-TARTRATE AND PRODUCTS OF SAID METHOD 2008
  • Aufdenblatten Roni
  • Bolin Martin Khans
  • Djukri Loren
  • Lindblad Ul'Rika
  • Magnusson Mattias
RU2477277C2

RU 2 464 266 C2

Authors

Lemehr Sebast'En Fransua Ehmmanjuehl'

Khorvat Andrash

Al'Terman Vim Al'Bert Aleks

Rammeloo Tomas Joakhim Landeval'D

Dates

2012-10-20Published

2007-11-09Filed