TETRAHYDROFURO(3,2-b)PYRROL-3-ONES AS CATHEPSIN K INHIBITORS Russian patent published in 2012 - IPC C07D491/48 A61K31/407 A61P19/08 A61P19/10 A61P35/04 

FIELD: medicine, pharmaceutics.

SUBSTANCE: present invention refers to compounds of formula (l) and their pharmaceutically acceptable salts wherein X represents CH or N; one of R¹ and R² represents H and the other one is specified in OR⁶, SR⁶, Me, Et and SOR⁸; R³ is specified in tert-butylmethyl, sec-butyl, tert-butyl, cyclopentyl and cyclohexyl; R⁴ cyclopentyl C_1-8alkyl optionally substituted by one C_1-6alkoxy group; or C_3-8cycloalkyl optionally substituted by one C_1-6alkoxy group; R⁶ represents C_1-8alkyl; and R⁸ represents C_1-8alkyl, as well as to based pharmaceutical compositions and applying them as cathepsin K inhibitors and for analysing the cathepsin K inhibitors specified above.

EFFECT: there are presented new biologically active compounds and using them in medicine and pharmaceutics.

12 cl, 79 ex, 2 tbl