RUMC PEPTIDES WITH ANTIMICROBIAL ACTIVITY Russian patent published in 2012 - IPC C07K9/00 C07K14/195 C12N15/31 C12N1/21 A23L1/54 

FIELD: chemistry.

SUBSTANCE: invention discloses RumC1, RumC2 and RumC3 peptides with antimicrobial activity, particularly on Clostridium perfringens, having molecular weight ranging from 4000 to 4600 Da and isolated from a mutant strain of Ruminococcus gnavus, deposited under number CNCM I-3705. The invention describes polynucleotides which code said peptides, an expression cassette which includes a promoter, said polynucleotide and a terminator sequence, as well as a polynucleotide-based cloning and expression vector. Described is a host organism which expresses said peptides, a composition having antimicrobial activity on Clostridium perfringens and containing a peptide, a host organism or a CNCM I-3705 strain, animal feed which is a food base and a composition.

EFFECT: use of the invention enables to produce a medicinal agent for preventing and treating diseases, particularly necrotic enteritis in pigs or poultry, and human gastrointestinal diseases.

16 cl, 9 dwg, 7 tbl