METHOD FOR INHIBITION OF MALIGNANT TUMOUR METASTASIS OR MALIGNANT CELL MIGRATION BY REDUCING CELL LEVEL OF LYSYL-tRNA-SYNTHETASE (VERSIONS), COMPOSITION AND APPLICATION OF EXPRESSION VECTOR OR KRS ANTIBODY FOR INHIBITION OF MALIGNANT TUMOUR METASTASIS OR MALIGNANT CELL MIGRATION Russian patent published in 2012 - IPC C12N15/09 C12N15/113 A61K31/7088 A61K48/00 A61P35/00

Abstract RU 2465330 C1

FIELD: medicine.

SUBSTANCE: what is offered is a method for inhibition of malignant tumour metastasis and tumour cell migration by reducing a KRS cell level. That is ensured by using an expression vector comprising a promoter and a functionally bound polynucleotide coding antisemantic RNA or siRNA of KRS polynucleotide, or the KRS antibody.

EFFECT: invention provides effective inhibition of malignant tumour metastasis by inhibition of the KRS function responsible for intensified tumour cell migration and observed with KRS translocation into a membrane and reaction with a laminin receptor.

8 cl, 33 dwg, 1 tbl

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RU 2 465 330 C1

Authors

Kim Sungkhoon

Choi Dzin Voo

Dates

2012-10-27—Published

2008-08-18—Filed