SELECTIVE ANTAGONISTS OF ADENOSINE A RECEPTORS Russian patent published in 2012 - IPC C07D473/34 A61K31/52 A61P25/32 A61P25/34 A61P19/00 A61P35/00 

FIELD: chemistry.

SUBSTANCE: compound, selected from compound given in Table 1 or in Table A correspond to general formulae: or . In Table 1 compounds are selected from compounds, where Y corresponds to NH or O; R² is selected from H, 2-fluorophenyl, furan-2-yl; group R⁴-R³- is selected from group =-CH₂-, tetrahydrofuran-3-yl, cyclopentyl, group -(CH₂)_qZ is selected from phenyl, substituted with CH₃, CF₃, Cl. In compounds, selected from Table A, R is selected from probably substituted phenyl, CH₂CH₂OB_n, where Bn stands for benzyl; X represents O; R⁹ is selected from propargyl and cyclopentyl.

EFFECT: compounds are selective antagonists of adenosine A_2a receptors and are suitable for manufacturing medication, useful in treatment of diseases, which require antagonistic action with respect to activity of said receptors.

6 cl, 2 tbl, 18 ex